transdermal ozone generates oxidative messengers that cross the skin barrier into circulation
Ozone acts on the superficial layer of human skin generating lipid oxidation products and reactive oxygen species (including unionised hydrogen peroxide) that can pass through the transcutaneous barrier and, enhanced by vasodilation, enter the systemic circulation.
What this means for you
When ozone contacts skin, it triggers the formation of small signaling molecules that can pass through the skin and enter the bloodstream — especially when blood flow near the surface is elevated. This is how a topical application may produce effects felt beyond the skin itself, supporting whole-body antioxidant and circulatory responses.
The published research
Eur J Appl Physiol (1999) 80: 549±554 Ó Springer-Verlag 1999
· 1999
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