Transdermal ozone introduces a controlled, mild oxidative signal that downregulates NF-κB — the master switch governing inflammatory gene expression — while simultaneously activating Nrf2, the body's
Reduced inflammation through NFκB suppression
What this means for you
Decreases chronic inflammation and associated pain
The published research
Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?
Medical gas research · 2011
This peer-reviewed review explicitly documents that ozone therapy, via moderate oxidative stress, activates Nrf2 which in turn suppresses NFκB and downstream inflammatory mediators (COX2, PGE2, cytokines). The mechanism of NFκB suppression leading to reduced inflammation is described directly in the abstract and elaborated in the full text (section 3.1 citing Li et al.).
This page describes a documented finding about the underlying wellness technology. It is not a marketing claim about any specific device. For information about HOCATT specifically, visit hocatt.com.