Transdermal ozone interacts with skin lipids to generate signaling molecules that boost local perfusion and oxygen delivery to tissues. The result is more oxygen reaching cells, where mitochondria use

transdermal-ozone well-supported
Increased tissue oxygenation

What this means for you

Enhanced cellular respiration and energy production

The published research

Ozone therapy: An overview of pharmacodynamics, current research, and clinical utility
Medical Gas Research ยท 2017
The review explicitly documents that ozone therapy increases oxygen delivery to tissues through multiple mechanisms: a rightward shift in the oxyhemoglobin dissociation curve via increased 2,3-DPG allowing readier unloading of oxygen to ischemic tissues, increased transmembrane O2 flow making mitochondrial respiratory chain more efficient, and improved perfusion. The abstract directly states O3 in
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