Transdermal ozone exposure introduces a brief, controlled oxidative signal that activates the Nrf2 pathway — the master regulator that switches on the body's own antioxidant enzyme production, includi
Activation of Nrf2 pathway leading to antioxidant enzyme production
What this means for you
Protects cells from oxidative damage and inflammation
The published research
Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?
Medical gas research · 2011
The review explicitly documents that moderate oxidative stress (as produced by ozone exposure) activates Nrf2, which then induces transcription of antioxidant response elements (ARE) and production of antioxidant enzymes including SOD, GPx, GST, catalase, HO-1, and NQO-1. This directly matches the response statement about Nrf2 pathway activation leading to antioxidant enzyme production. The mechan
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