transdermal ozone triggers a cascade that upregulates the body's own antioxidant enzymes

Ozone reacting with polyunsaturated fatty acids in biological fluids generates hydrogen peroxide and lipid oxidation products (LOPs) that act as signaling molecules, upregulating antioxidant enzymes including superoxide dismutase, glutathione peroxidase, glutathione reductase, and catalase.

What this means for you

Your body makes its own antioxidant defenses — enzymes like SOD and catalase that neutralize the oxidative stress linked to aging, inflammation, and slow recovery. This finding shows that ozone contact with skin lipids can signal your cells to produce more of these enzymes, essentially prompting your body to strengthen its own internal cleanup system.

The published research

www.centauro.it Rivista Italiana di Ossigeno-Ozonoterapia 5: 93-104, 2006
· 2006
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