transdermal ozone suppresses key inflammatory signaling pathways linked to skin inflammation
Ozone therapy inhibits the NF-κB pathway at therapeutic doses by suppressing TLR2, P50, and P65 expression, reducing pro-inflammatory cytokines (IL-17A, IL-17C, IL-17F, IL-1β, IL-8, IL-22, TNF-α) and chemokines (CXCL1, CXCL2, CXCL3) in psoriatic lesions.
What this means for you
When inflammatory signaling quiets down, the skin's overactive immune response tends to calm with it — meaning less redness, irritation, and cellular stress. For anyone dealing with chronic skin flare-ups or general inflammation, lower levels of these pro-inflammatory messengers is exactly the direction you want your body moving in.
The published research
Ozone therapy for skin diseases: Cellular and molecular mechanisms.
International wound journal · 2023
This page describes a documented finding about the underlying wellness technology. It is not a marketing claim about any specific device. For information about HOCATT specifically, visit hocatt.com.