ozone preconditioning helps preserve dopamine levels in brain tissue under oxidative stress

Ozone preconditioning (rectal insufflation at 25 µg/ml, 0.7 mg/kg, 20 sessions) significantly preserved striatal dopamine levels in rotenone-treated rats (7.700 vs 6.300 µg/g tissue in rotenone-only group), approaching normal control values (7.813 µg/g tissue).

What this means for you

Dopamine is the brain chemical behind motivation, focus, and feeling rewarded. When oxidative stress depletes it, energy and mood can take a hit. Research suggests ozone preconditioning may help the brain hold onto dopamine under stress — which could support steadier mood, mental drive, and cognitive resilience over time.

The published research

protects against Rotenone-
· 2004
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