ozone exposure triggers a plasma-soluble factor that activates immune cells

Dilution of ozonated blood 1:100 (plasma elimination model) abolished the stimulating effect of ozone on neutrophil SCL and ICL in vitro, confirming that the active immunostimulatory factor is a plasma-soluble substance rather than a direct cellular effect of ozone.

What this means for you

When ozone contacts the bloodstream, it appears to prompt the release of a signaling substance in plasma that wakes up immune cells — rather than stimulating them directly. This suggests your body's own chemistry is doing the work, which is a more natural and sustainable way to support immune readiness and resilience.

The published research

The Mechanism of the Anti-Inflammatory Effect of
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