ozone nucleolysis shows low pain aggravation rate (~6%) at 2 and 6 months

Pain aggravation was reported in only 6.3% of patients at 2 months and 6.6% at 6 months following O2-O3 nucleolysis, indicating a low adverse event rate.

What this means for you

A low rate of pain aggravation — around 6% at both 2 and 6 months — suggests ozone-based disc procedures are generally well-tolerated over time. For anyone exploring options for back discomfort, a strong safety profile matters as much as effectiveness. This finding points to a favorable response pattern in the months following the procedure.

The published research

Outcome of Disk Nucleolysis by
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