transdermal ozone activates the body's master antioxidant switch, boosting protective enzymes
Ozone therapy activates the Nrf2 transcription factor pathway, inducing antioxidant response elements (ARE) and increasing concentrations of SOD, GPx, GST, catalase, HO-1, NQO-1, heat shock proteins, and phase II drug metabolism enzymes.
What this means for you
Your body has a built-in defense system against oxidative stress — the kind that drives aging, inflammation, and low energy. When this pathway switches on, it floods your cells with protective enzymes like SOD and catalase. Most people associate this kind of internal resilience with better recovery, clearer skin, and feeling less worn down over time.
The published research
Ozone therapy: An overview of pharmacodynamics, current research, and clinical utility
Medical Gas Research · 2017
This page describes a documented finding about the underlying wellness technology. It is not a marketing claim about any specific device. For information about HOCATT specifically, visit hocatt.com.