high-dose ozone triggers sustained neutrophil enzyme release lasting up to 24 hours
Ozone exposure induces dose-dependent myeloperoxidase (MPO) release from neutrophil azurophilic granules, with low-dose ozone (30 µg/mL) producing only modest transient changes while high-dose ozone (90 µg/mL) causes sustained MPO elevation up to 24 hours.
What this means for you
Neutrophils are your immune system's first responders. When ozone prompts them to release enzymes like MPO, it signals an active oxidative response — the kind your body uses to clear cellular debris and support tissue defense. Understanding this dose-dependent effect helps explain why ozone concentration matters when supporting immune and recovery responses.
The published research
Mild Ozone-Induced Oxidative Stress Modulates the Activity and Viability of Porcine Neutrophils and Monocytes
Animals · 2026
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