ozone exposure rapidly reduces IL-4 cytokine output in immune cells within 24 hours
IL-4 production by PBMC was markedly decreased even at the lowest ozone concentration tested (2.5 µg/ml) already after 24 hours of incubation, indicating high sensitivity of Th-2 cytokine production to ozone.
What this means for you
IL-4 is a signaling molecule tied to the overactive immune responses many people associate with seasonal discomfort and skin reactivity. When ozone exposure dials it down quickly, it suggests the body's inflammatory signaling may become more balanced — something people often notice as less puffiness, calmer skin, or easier breathing during high-allergen periods.
The published research
This page describes a documented finding about the underlying wellness technology. It is not a marketing claim about any specific device. For information about HOCATT specifically, visit hocatt.com.