transdermal ozone upregulates heat shock proteins linked to cellular protection

Ozone therapy upregulates HO-1 (Hsp32) and Hsp70, providing cytoprotective effects relevant to inflammation, cancer, aging, and neurodegenerative disorders through the heat shock response.

What this means for you

Heat shock proteins are your cells' built-in repair crew — they refold damaged proteins, clear out cellular debris, and help protect against the wear-and-tear tied to inflammation and aging. When ozone exposure nudges these proteins upward, it may support your body's natural resilience at the cellular level, which most people associate with feeling more recovered, clearer, and less run-down over time.

The published research

Ozone therapy: An overview of pharmacodynamics, current research, and clinical utility
Medical Gas Research · 2017
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