ozone stimulates oxygen-release molecule (DPG) in red blood cells, with effect declining in older cells

The ability of ozone to stimulate DPG synthesis in stored RBCs decreases with increasing storage duration: 13-day stored cells reached up to 250 µmol DPG/4.5×10¹² cells, while 34-day stored cells reached only approximately 60 µmol/4.5×10¹² cells under simulated transfusion.

What this means for you

DPG is the molecule that tells your red blood cells to actually release oxygen into your tissues. When ozone supports DPG activity, your cells may deliver oxygen more efficiently — which matters for energy, mental clarity, and how well your body recovers from physical stress.

The published research

The Influence of Ozone on 2,3-Diphosphoglycerate
· 1992
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