transdermal ozone triggers immune-signaling cytokine release at a specific dose threshold
Ozone therapy at a concentration of 40 µg/mL (8 mg dose) is effective for cytokine release, while at 20 µg/mL (4 mg dose) cytokine release is insignificant, establishing a dose-response threshold for immunomodulation.
What this means for you
Cytokines are the body's internal messengers that coordinate immune responses and recovery. When ozone concentration reaches the right level, it appears to activate this signaling system — which may support your body's natural ability to respond to stress, inflammation, and cellular repair. Think of it as nudging your immune system to pay attention.
The published research
Changes in Glutathione Antioxidant Pathway Components,
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