low-dose ozone shifts L-arginine metabolism toward tissue repair pathways in immune cells
Low-dose ozone (30 µg/mL) increased neutrophil arginase activity, which competes with nitric oxide synthase for L-arginine, potentially reducing nitric oxide production while promoting ornithine, proline, and polyamine synthesis associated with tissue repair.
What this means for you
Your body's repair process depends on the right raw materials getting to the right place. When L-arginine is redirected toward producing ornithine and proline — building blocks for collagen and new tissue — your cells are essentially primed for recovery. This kind of metabolic shift is associated with how the body responds to and bounces back from physical stress.
The published research
Mild Ozone-Induced Oxidative Stress Modulates the Activity and Viability of Porcine Neutrophils and Monocytes
Animals · 2026
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