extended light exposure downregulates a key circadian signaling receptor in the brain's clock center
Long photoperiod entrainment significantly downregulates prokineticin receptor 2 (Prokr2) expression in the SCN, potentially reconfiguring the PROK2 signaling network hub that is widely expressed across SCN neurons.
What this means for you
Your body's internal clock is regulated by light-sensitive signaling in a region of the brain called the SCN. When light exposure shifts how that signaling network is expressed, it can influence how your circadian rhythm adapts — which most people feel as changes in sleep timing, energy patterns, and mood across seasons or after disrupted schedules.
The published research
Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice
Journal of Biological Rhythms · 2024
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