whole-body hyperthermia increases expression of a surface protein linked to B cell activity
Whole-body hyperthermia upregulates CLEC17A (C-type lectin domain containing 17A), a surface protein thought to play a role in proliferating B cells, as identified by differentially expressed gene analysis.
What this means for you
B cells are a key part of your immune system — they produce antibodies and help your body recognize and respond to threats. When a protein associated with their activity goes up, it may reflect a more engaged immune response. This is one of the ways heat exposure appears to interact with immune function at a cellular level.
The published research
Whole-blood transcriptomic response to whole-body hyperthermia in participants with major depressive disorder
Brain, Behavior, & Immunity - Health · 2026
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