heat-induced HSP70 proteins suppress inflammatory signaling in blood vessel cells
Heat-shock proteins, specifically HSP70, modulate the innate immune system by interfering with NF-κB activation, thereby suppressing expression of proinflammatory cytokines including tumor necrosis factor and proinflammatory IL-6 trans-signaling in endothelial cells.
What this means for you
When your body heats up, it produces protective proteins that help dial down overactive inflammation at the cellular level. Chronic low-grade inflammation is linked to fatigue, joint discomfort, and accelerated aging — so supporting your body's natural ability to keep it in check matters for how you feel day to day.
The published research
Whole-blood transcriptomic response to whole-body hyperthermia in participants with major depressive disorder
Brain, Behavior, & Immunity - Health · 2026
This page describes a documented finding about the underlying wellness technology. It is not a marketing claim about any specific device. For information about HOCATT specifically, visit hocatt.com.