high-dose ozone exposure reduces superoxide dismutase (SOD) activity in tissue

At high doses (2.5 mg/kg), ozone caused a significant decrease in SOD activity below cisplatin-treated control levels, demonstrating a dose-dependent deleterious effect on antioxidant enzymes at excessive concentrations.

What this means for you

This finding is a caution, not a benefit: at excessive concentrations, ozone can actually suppress one of your body's key antioxidant enzymes rather than support it. It's a reminder that dose matters — more is not always better, and staying within evidence-based ranges is essential for safe, effective use.

The published research

Mediators of Inflammation, 13(1), 13 /19 (February 2004)
· 2004
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