transdermal ozone activates HIF-1α, stimulating new blood vessel growth and oxygen delivery
Ozone therapy activates hypoxia inducible factor-1α (HIF-1α) via moderate oxidative stress, resulting in increased VEGF, erythropoietin (EPO), and glycolytic enzymes that enhance neoangiogenesis, erythropoiesis, and oxygen delivery to ischemic tissues.
What this means for you
When your body grows new blood vessels and produces more oxygen-carrying red blood cells, tissues get better fuel — which most people notice as improved stamina, faster recovery, and a general sense of vitality. This is the same pathway elite athletes and altitude training tap into, happening at a cellular level.
The published research
Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?
Medical gas research · 2011
This page describes a documented finding about the underlying wellness technology. It is not a marketing claim about any specific device. For information about HOCATT specifically, visit hocatt.com.