transdermal ozone activates a protective protein that releases natural antioxidants into cells

Ozone therapy induces upregulation of heme oxygenase-1 (HO-1/HSP-32), which delivers cytoprotective compounds including carbon monoxide and bilirubin, the latter being a significant lipophilic antioxidant.

What this means for you

When this protein switches on, your body produces bilirubin — a fat-soluble antioxidant that helps neutralize cellular damage from the inside out. It also releases a trace of carbon monoxide that works alongside other signaling molecules to support healthy blood vessel tone. Together, these responses point toward better cellular resilience and circulation support.

The published research

www.centauro.it Rivista Italiana di Ossigeno-Ozonoterapia 5: 93-104, 2006
· 2006
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