heat exposure activates heat shock proteins, supporting cellular stress response
Activation of heat shock proteins
What this means for you
Protects cells from stress and supports cellular repair
The published research
Whole-blood transcriptomic response to whole-body hyperthermia in participants with major depressive disorder
Brain, Behavior, & Immunity - Health · 2026
The study directly documents WBH-induced activation of heat shock proteins, with HSP-encoding genes representing 41% of differentially expressed genes, including upregulation of multiple HSP70 (HSPA1A, HSPA1B), HSP90 (HSP90AA1, HSP90AB1), and HSP110 (HSPH1, HSPA4) family members. GSEA also confirmed enrichment of heat-shock response biological processes including 'chaperone mediated protein foldin
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