elevated core temperature correlates with increased cell-free DNA release during exercise
Core body temperature was significantly correlated with exercise-provoked release of cell-free DNA (cfDNA) (r = 0.583, p = 0.012), with core temperature identified as an independent contributor to elevated neutrophil cfDNA in response to exercise.
What this means for you
Cell-free DNA is a natural signaling molecule your immune system uses to coordinate recovery and adaptation after physical stress. When core temperature rises during exertion, the body appears to release more of it — a response linked to how your immune cells mobilize and communicate. This suggests that heat-driven temperature elevation may play a role in priming your body's post-activity recovery signaling.
The published research
Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes
Physiological Reports · 2025
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