hyperthermia activates brown fat and raises core body temperature via TRPM2 signaling
Intracerebroventricular injection of ADPR increased BAT temperature (from 36.4 ± 0.1 °C to 37.5 ± 0.1 °C) and core body temperature (from 36.2 ± 0.1 °C to 37.5 ± 0.1 °C) in NCD-fed mice, with the increase blocked by TRPM2 antagonist pretreatment.
What this means for you
Brown fat is your body's built-in heat-generating tissue — when it activates, it burns energy and helps regulate metabolism. Supporting this thermal response may contribute to better energy balance, warmth regulation, and metabolic resilience over time.
The published research
The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis
Experimental & Molecular Medicine · 2025
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